Dusting Powder Presentation

CLOTRIMAZOLE 1% W/W 100 g

Clotrimazole belongs to imidazole category of azole antifungal class of drugs. It has broad-spectrum activity. It is used for the treatment of sickle cell anemia, malaria and cancer. It is fungistatic in nature and inhibits yeast by causing alteration in its cell membrane.

Indications

• Candidiasis
• Vaginal yeast infections
• Tinea pedis
• Tinea cruris
• Ringworm

Mechanism of Action

Clotrimazole inhibits the synthesis of ergosterol which is the component of fungal cell membrane by inhibiting 14-alpha demethylase. This enzyme prevents the conversion of lanosterol to ergosterol. thus, decreases the growth of fungal cells.

Pharmacokinetics

Absorption- It is absorbed orally
Protein Binding- It shows 98% bound to proteins
Metabolism- It is metabolized in the liver

Side Effects

• Rashes
• Fever
• Chills
• Nausea
• Vomiting
• Vaginal discharge

Drug Interactions

• Duloxetine
• Diphenhydramine
• Fluticasone
• Betamethasone

Contraindication

• Contraindicated in people with known hypersensitivity